Medium power: DQ stain
Numerous large atypical lymphoid cells
High power: DQ stain
Large lymphoid cells with round to irregular nuclei and vacuolated cytoplasm
High power: DQ stain
Large lymphoid cells with round to irregular nuclei and basophilic cytoplasm
High power: DQ stain
PEL cells with round to irregular nuclei, rare prominent nucleoli, and vacuolated cytoplasm
High power: DQ stain
Large lymphoid cells with plasmablastic and immunoblastic features
High power: DQ stain
Large lymphoid cells with round to irregular nuclei and vacuolated cytoplasm
High power: DQ stain
Large lymphoid cells with round to irregular nuclei and basophilic, vacuolated cytoplasm
High power: Pap stain
Large lymphoid cells with irregular nuclei, frequent nucleoli and moderate to abundant cytoplasm
High power: Pap stain
Large lymphoid cells with round to irregular nuclei, frequent nucleoli and moderate to abundant cytoplasm
High power: Pap stain
Large lymphoid cells with irregular nuclei, frequent nucleoli and moderate to abundant cytoplasm
Features
• Body-cavity based large B-cell lymphoma associated with human herpesvirus (HHV-8) without any detectable tumor mass. Often seen in setting of immunodeficiency e.g. HIV infection or rarely post-transplant. Often co-infection with EBV.
• Dispersed large markedly atypical lymphoid cells
• Plasmablastic or immunoblastic to anaplastic
• Moderate to abundant basophilic cytoplasm
• Cytoplasmic vacuoles may be present
• Large round irregular nuclei
• Anaplastic multilobated nuclei may be present
• Prominent nucleoli
• May have perinucleolar hof
• Mitosis present
• Apoptotic bodies may be seen
• IHC: Usually express CD45, but negative for CD19, CD20 and CD79a, surface immunoglobulin. Always positive for HHV8, usually positive for EBV by EBER ISH but negative for EBV LMP1. Morphologically similar to diffuse large B cell lymphoma and IHC help differentiate.
• Nador RG et al. Blood. 1996 Jul 15;88(2):645-56.