Low power: DQ stain
Cellular smear with small basaloid cells and hyaline material, metachromatic on DQ stain
Medium power: DQ stain
Cellular smear with small basaloid cells surrounded by hyalinized stromal material and hyaline globules, metachromatic on DQ stain
Medium power: Pap stain
Cellular smear with small basaloid cells surrounding hyalinized stromal material, pale translucent on Pap stain
High power: Pap stain
Small basaloid cells with round uniform nuclei, rare small nucleoli, slightly coarse chromatin, with pale and translucent hyalinized stroma
High power: Pap stain
Small basaloid cells with round nuclei, some nuclear atypia, slightly coarse chromatin, with pale and translucent hyalinized stroma
High power: Pap stain
Small basaloid cells with round nuclei with nuclear atypia, rare small nucleoli, slightly coarse chromatin, with pale and translucent hyalinized stroma
High power: Pap stain
Small basaloid cells with round nuclei with nuclear atypia, rare small nucleoli, slightly coarse chromatin, with pale and translucent hyalinized stroma
Cell block: H&E stain
Cribriform arrangement of adenoid cystic carcinoma
Cell block: H&E stain
Small uniform basaloid cells with cribriform arrangement
Features
• Cellular smears
• Small basaloid cells
• Cribriform, rosettes, tubular clusters
• Basaloid cells with metachromatic hyaline material
• Small, uniform, relatively bland basaloid cells
• Scant cytoplasm
• Cells surrounded by hyalinized stroma
• Cells are arranged around pseudoglandular spaces containing basement membrane• like material
• Nuclei small, round to oval, rare atypia
• Chromatin may be coarse
• Rare visible small nucleoli
• Numerous naked nuclei
• Metachromatic homogenous hyaline material: globules or cylinders
• Rare mitosis or necrosis
• Express cytokeratin, vimentin, SMA, calponin, p63, S100
Qiu S et al. Diagn Cytopathol. 2004 Jan;30(1):51-6.