Large malignant cells in clusters and singly with enlarged round nuclei, prominent nucleoli and moderate amount of cytoplasm.
Large malignant predominantly singly dispersed with enlarged round nuclei, occasionally with eccentric location, prominent nucleoli and moderate amount of cytoplasm.
Large malignant cells in clusters and singly with enlarged round nuclei, coarse chromatin, prominent nucleoli and moderate amount of cytoplasm.
Features
• Very cellular smears
• Single cells, sheets or clusters
• High grade adenocarcinoma-like features
• Large polygonal cells
• Often singly dispersed
• Scant to abundant cytoplasm
• May have vacuolated or granular cytoplasm
• Intracytoplasmic mucin usually absent
• Nuclei enlarged, round to oval
• Coarse chromatin
• Prominent nucleoli
• Necrosis present
• Frequent mitosis
• Express cytokeratin, CK7, EMA, Androgen receptor, CK20+/- , GCDFP-15 +/- , may express S100, vimentin, CD117, PSA, calponin
Elsheikh TM et al. Diagn Cytopathol. 1994;11(1):47-51.