DQ stain: Low power
Crowded 3D clusters of malignant cells. Note scattered dispersed single cells
DQ stain: High power
Malignant cells with enlarged, irregular nuclei and vacuolated cytoplasm
DQ stain: High power
Malignant cells in crowded clusters with enlarged, irregular nuclei and vacuolated cytoplasm. Note single cells in the background
Pap stain: Low power
Malignant cells in 3D clusters. Note mucin in the background
Pap stain: Medium power
Crowded clusters of malignant cells with enlarged, irregular nuclei, coarse chromatin and vacuolated cytoplasm
Pap stain: Medium power
Crowded 3D clusters of malignant cells with enlarged, irregular nuclei, coarse chromatin and vacuolated cytoplasm. Background shows granular debris
Pap stain: High power
Malignant cells with enlarged, irregular nuclei, coarse chromatin and vacuolated cytoplasm
Pap stain: High power
Malignant cells with enlarged, irregular nuclei, coarse chromatin and vacuolated cytoplasm. Note mitotic figure
H&E stain: Cell block
Clusters of malignant cells with intracytoplasmic mucin. Note occasional nuclei being pushed to periphery to give signet ring appearance
H&E stain: Cell block
Clusters of malignant cells with intracytoplasmic mucin. Note signet ring like cells
H&E stain: Cell block
Clusters of malignant cells with irregular pleomorphic nuclei and intracytoplasmic mucin. Note mitotic figure
Features
• Rare (<2% of bladder cancer)
• Often mixed component with urothelial carcinoma
• 2 types: colonic (more common) and signet ring (rare)
• Crowded 3D clusters
• Signer ring type may have predominantly single cells
• Cuboidal to columnar cells
• Vacuolated cytoplasm
• May have cytoplasmic mucin and signet ring cells
• Enlarged, irregular , pleomorphic nuclei
• Coarse chromatin
• Prominent nucleoli
• Mucin may be present
• Necrotic debris
• Mitosis may be present
• Bardales, RH et al. Cancer. 1998 Dec 25;84(6):335-43.
• DeMay, RM et al. Acta Cytol. 1985 Mar-Apr;29(2):132-6.
• Trillo, AA et al. Acta Cytol. 1981 May-Jun;25(3):285-90.