Low power: DQ stain
High grade follicular lymphoma with many centroblasts
Low power: Pap stain
High grade follicular lymphoma with many centroblasts
Low power: Pap stain
Low-grade follicular lymphoma with germinal center fragments composed of predominately small lymphocytes
High power: DQ stain
High grade follicular lymphoma with centrocytes and many centroblasts
High power: Pap stain
High grade follicular lymphoma with centrocytes and many centroblasts
High power: Pap stain
Low grade follicular lymphoma composed predominately of small cleaved lymphocytes
High power: cell block
Low grade follicular lymphoma with predominately small to intermediate sized cleaved lymphocytes
Features
• Dispersed lymphoid cells
• May form lymphoid aggregates
• Mix of centrocytes and centroblasts
• Centrocytes are small to medium-sized lymphoid cells
• Centroblasts are large cells
• Centrocytes
- angulated or cleaved nuclei
- inconspicuous nucleoli
• Centroblasts
- round to oval nuclei
- vesicular chromatin
- 1 to 3 peripheral nucleoli
• Typically positive for Pan-B-cell markers, CD10
* Negative for CD5 and CD43
• Typically express CD45 (bright), CD19, CD20, CD10; kappa or lambda light-chain restriction
• Negative for CD5
• t(14;18)(q32;q21) in 80-90% cases
• Caraway NP, Stewart JM. Follicular lymphoma. Diagnostic Pathology Cytopathology. First Edition. DR Mody. Manitoba: Amirsys, 2014. III-4-28-III-4-29. Print.
• Harris NL, Swerdlow SH et al. Follicular lymphoma. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Fourth Edition. Steven H. Swerdlow. Lyon: 2008. 220-226. Print.