Features

Architecture

• Predominantly cystic background
• Motor oil-like greenish-brown thick fluid
• Dual population of oncocytes and lymphocytes

Cellular features

• Large oncocytic cells
• Granular cytoplasm
• Reactive lymphocytes (may predominate)

Nuclear features

• Small to enlarged
• Prominent nucleoli
• May have binucleation

Background

• Cyst content: granular or mucoid
• Lymphoid tangles
• Lymphohistiocytic aggregates
• Lymphoglandular bodies
• May have mast cells
• Macrophages, cellular debris
• Necrosis may be present
• Mitosis rare to absent

Reference

Parwani AV et al. Cancer. 2003 Jun 25;99(3):166-71.
Veder LL et al. Head Neck. 2010 Dec;32(12):1635-40.