Low power: DQ stain
Large cohesive fragments of tubular carcinoma
Low power: Pap stain
Large cohesive fragments of tubular carcinoma
Note occasional stromal fragments
Medium power: Pap stain
Cohesive fragments of tubular carcinoma showing tubular structures and angular arrowheads
Medium power: Pap stain
Minimal nuclear atypia with bland uniform cells with rare nuclear membrane irregularity and small nucleoli
High power: Pap stain
Angular pointed arrowhead-like structures characteristic of tubular carcinoma
Note minimal nuclear atypia with rare cells showing nuclear membrane irregularity and small nucleoli
High power: Pap stain
Minimal nuclear atypia with bland uniform cells with rare nuclear membrane irregularity and small nucleoli
High power: Pap stain
Minimal nuclear atypia with bland uniform cells with rare nuclear membrane irregularity and small nucleoli
Note psammomatous calcification
Features
• Typically cohesive clusters
• Sheets of cells with minimal atypia
• Tubular and angular (arrowhead-like) structures
• Well-differentiated cells
• Minimal atypia
• Mild nuclear enlargement
• Fine chromatin
• Inconspicuous to small nucleoli
• May have nuclear irregularity focally
• May have intranuclear cytoplasmic inclusions
• May have naked bipolar nuclei
• May have stromal fragments
• Necrosis rare
• Express cytokeratin, CK19, ER, PR, Androgen receptor, may express E-cadherin
Cangiarella J et al. Diagn Cytopathol. 2001 Nov;25(5):311-5.
Bondeson L et al. Acta Cytol. 1990 Jan-Feb;34(1):15-20.