DQ stain: Low power
Hypocellular smear with fragments of metachromatic matrix.
DQ stain: Medium power
Small uniform cells with round nuclei in cartilaginous fragments.
DQ stain: High power
Small uniform cells with round nuclei in cartilaginous fragments
Pap stain: Low power
Hypocellular smear with fragments of cartilage
Pap stain: Medium power
Small uniform cells embedded in cartliaginous fragments
Pap stain: Medium power
Small cohesive cluster of uniform cells with round uniform nuclei
Pap stain: High power
Small uniform cells in lacunar spaces embedded in cartilaginous fragments
Features
• Most common benign neoplasm
• Usually diagnosed by characteristic radiologic appearance
• Paucicellular
• Cartilagenous fragments
• Chondrocytes in lacunar spaces
• May have pleomorphism when malignant transformation
• Nuclei small and regular
• Nuclear pleomorphism may indicate malignant transformation
• Cartilaginous matrix (metachromatic)
• No necrosis or mitosis
• Myxoid matrix may indicate malignant transformation
• IHC: positive for S100; negative for cytokeratin