Pap stain, high power:
Bronchial epithelial cell with nuclear enlargement
Note Cowdry A type, eosinophilic inclusions
DQ stain, high power:
Bronchial epithelial cells with multinucleation and honey comb like nuclei
Note basophilic inclusions with loss of chromatin detail
DQ stain, high power:
Note basophilic inclusions with smudgy chromatin
DQ stain, high power:
Note basophilic inclusion with large irregular nuclear contour
Features
Specimen in which encountered
• Cellular smears
• Small groups or single cells
• Koilocyte• like cells
Cellular features
• Two types of inclusions:
– Basophilic nuclear inclusions
– Eosinophilic, Cowdry-like inclusion
• Smudgy chromatin
• Nuclei with honey-comb appearance
• In BAL specimens: Ciliocytophthoria
Reference
Acta Cytol. 1991 Mar-Apr; 35(2):181-2