Low power: DQ stain
Monotonous population of oncocytic cells with small round eccentrically located nuclei and abundant granular cytoplasm.
High power: DQ stain
Monotonous population of oncocytic cells with small round eccentrically located nuclei and abundant granular cytoplasm.
High power: Pap stain
Oncocytic cells with small round eccentrically located nuclei, occasional binucleation, fine chromatin, conspicuous nucleoli and abundant granular cytoplasm.
Cell block: H&E stain
Rounded nests of monotonous oncocytic cells.
Cell block: H&E stain
Rounded nests of monotonous oncocytic cells
Features
• Cellular smears
• Monotonous population of oncocytic cells
• Single cells, loose clusters, round nests
• Large round to polygonal cells
• Granular cytoplasm
• Well-defined borders
• Small round nuclei
• Eccentrically located nuclei
• Fine chromatin
• Binucleation
• Conspicuous to prominent nucleoi
• Mitoses absent
• Necrosis absent
• Often best to diagnose as oncocytic neoplasm on FNA and small biopsy; Need to differentiate from chromophobe CA and RCC with granular features
• Express cytokeratin, EMA, CD117; typically negative for vimentin, CK7, Hales colloidal iron (D/D chromophobe ca).
• May have loss of chromosomes 1 or Y, or translocation 11q13
Alanen KA et al. Acta Cytol. 1985 Sep-Oct;29(5):859-62.