Pap stain, high power:
Macrophage with nuclear enlargement and eosinophilic intranuclear inclusion
Pap stain, high power:
Binucleation with intranuclear inclusions giving owl-eye appearance
Pap stain, high power
Pneumocytes with basophilic intranuclear inclusions
Fine granular cytoplasmic inclusions
Anti-CMV immunostain, high power:
Note both cytoplasmic granular staining and large cell with nuclear staining
Features
Specimen in which encountered
• Bronchioloalveolar lavage or washing
• Cerebrospinal fluid
Cellular features
• Two types of inclusions:
– Large, basophilic nuclear inclusions
– Small eosinophilic cytoplasmic inclusions
• Cell and nuclear enlargement
• Binucleation gives Owl-eye appearance
Reference
Weiss et al. Diagn Cytopathol. 1991; 7:243-27