Medium power: Pap stain
Urothelial cells with round nuclei, bland chromatin and granular cytoplasm
Medium power: Pap stain
Urothelial cells with round nuclei, bland chromatin and dense cytoplasm
High power: Pap stain
Urothelial cells with round nuclei, bland chromatin and granular cytoplasm
Medium power: Pap stain
Urothelial cells with columnar change
More common in instrumented urine
HIgh power: pap stain
Oxalate crystals
Tetrahedral envelope-like crystals can be often seen in urine
Medium power: pap stain
Lubricant (from procedure)
Amorphous purple matrix-like material in the background
May obscure cells of interest
High power: Pap Stain
Corpora amylaceum
Concentric laminated noncalcified bodies dervied from prostatic secretions
Features
• Urothelial cells (deep and superficial)
• Voided urine usually single cells
• Papillary clusters in instrumentation, calculi, infection or low grade urothelial lesions
• Small cells (10um) to large superficial (umbrella) cells (100um)
• Round to triangular to polyhedral cells
• Cytoplasm can be granular to dense to vacuolated
• Round and small nuclei
• May be binucleated
• Superficial cells can be multinucleated
• Bland chromatin
• Usually clean
• May have contaminating squamous cells (genital tract)
• May have blood
• Crystals
• Casts
• Inflammation
• Multinucleated giant cells (e.g. BCG therapy)