Low power: DQ stain
Cellular smears with papillary structures and large cells.
Low power: DQ stain
Cellular smears with large cells with round to irregular nuclei and abundant cytoplasm.
Low power: DQ stain
Cellular smears with papillary structures with fibrovascular cores.
Low power: DQ stain
Cellular smears with papillary structures with fibrovascular cores lined by large cells with round to irregular nuclei, fine to coarse chromatin and prominent nucleoli
Low power: DQ stain
Cellular smears with large pleomorphic cells with round to irregular nuclei, fine to coarse chromatin and prominent nucleoli.
Cell block: H&E stain
Cellular with papillary structures.
Cell block: H&E stain
Cellular with papillary structures with fibrovascular cores lined by large cells with round nuclei, prominent nucleoli and abundant cytoplasm.
Features
• Cellular smears
• Papillary with fibrovascular cores
• Pseudostratified large pleomorphic cells
• Foamy macrophages
• Hemosiderin pigmentation
• Large round to irregular nuclei
• Fine to coarse chromatin
• Prominent nucleoli
• Hemorrhagic
• Necrotic
• Express cytokeratin, EMA, CD10, RCC, AMACR; vimentin +/- ; negative for CD117, CK7
• May have Trisomy chromosome 7, 16 or 17, loss of Y
Granter SR et al. Cancer. 1998 Oct 25;84(5):303-8.